Pharmaceutical Intelligence Platform

Dissolution Analysis,
Reimagined.

Professional-grade dissolution modeling, f2 similarity, and compliance engine — in one streamlined web platform. No installs, no macros.

Launch DissolvA™ Free → Watch Tutorial
62
Kinetic Models
FDA
Guideline Compliant
USP/EP
Monograph Engine
Free
Core Features
Live Platform
See it in action.
A real dissolution analysis — from data upload to compliance verdict in under 3 minutes.
dissanalyze.streamlit.app
Analysis
Data Input
Kinetic Fitting
f1 / f2 Similarity
Bootstrap f2
Tools
Statistical Analysis
Excel Report
Settings
Method Settings
Data Input — Ibuprofen 400mg
3 profiles loaded · USP II · 900 mL · pH 6.8 · 50 rpm · Q = 80% at 45 min
✓ PASS
Reference · 87.2% @ 45 min
✓ PASS
Test A · 82.6% @ 45 min
✗ OOS
Test B · 73.1% @ 45 min
Cumulative Drug Released (%)
Platform Overview
Watch how it works.
Step-by-step walkthrough — from uploading your dissolution data to generating a regulatory-ready Excel report.
A
DissolvA™
Pharmaceutical Intelligence Platform
FDA · EMA · USP Compliant
62 Kinetic Models
Powered by AI
f1 / f2 Similarity Analysis
Reference
PASS
87.2% @ 45 min
Test A
PASS
82.6% @ 45 min
Test B
OOS — Out of Spec
73.1% @ 45 min · Below Q limit of 80%
f2 Similarity Factor
Test A vs Reference
68.4
SIMILAR (>50)
Kinetic Model Library
62
Dissolution Models
Zero Order
First Order
Higuchi
Korsmeyer-Peppas
Weibull
Hixson-Crowell
Baker-Lonsdale
Hopfenberg
Peppas-Sahlin
+ 52 more
Regulatory Compliance Engine
FDA
1997 Guidance
EMA
CHMP/QWP
USP
Monographs
CV criterion — time-based (FDA: t≤15 min, EMA: t≤10 min)✓
85% single-point rule — first exceeding point included✓
OOS / OOT automatic flagging✓
Bootstrap f2 Analysis
Parametric
Shah 1998
f2 = 68.4
95% CI: [61.2 — 74.8]
Nonparametric
Bootstrap
f2 = 67.9
95% CI: [60.8 — 73.5]
Both methods confirm similarity (f2 > 50)
SIMILAR
Start today — free forever
Ready to modernize your
dissolution workflow?
No install · No subscription · FDA & EMA compliant
62 models · Bootstrap f2 · Professional Excel reports
Launch DissolvA™ Free →
www.dissolva.app
DissolvA™ — Predictive Dissolution Suite
4s
Powered by AI
Core Capabilities
Everything you need
in one place.
From raw vessel data to regulatory-ready reports — no Excel macros, no local installs required.
Intelligent Compliance Engine
USP/FDA monograph compliance verified at Q-time via interpolation. Instant OOS flagging with academic root-cause analysis and ICH Q6A recommendations.
f1 / f2 Similarity Analysis
FDA-compliant f1 and f2 calculation with 85% cutoff, Q-value and Q-time overlays, error bars, and automatic boundary-zone warnings when f2 is in the 45–55 range.
62 Kinetic Models
Zero-order to Gompertz, Weibull variants, sigmoid, burst-release, and fractal models. More models than DDSolver (40), KinetDS (15), or RKinetDS (36).
Excel Report Engine
8-sheet professional reports with logo upload, project metadata, bootstrap results, dissolution charts, and similarity reports — all generated in one click.
Smart Profile Management
Session persistence across all pages. Profile renaming syncs globally across all analyses. Project metadata — name, analyst, description — flows into report headers automatically.
Statistical Analysis
MDT, DE, pooled statistics, per-profile tables with SD/RSD. Individual profile plots with error bars, Q-line overlays, and USP acceptance criterion annotation.
Predictive Dissolution Suite
Model Library
62 Kinetic Models — by Category
From zero-order to fractal kinetics — the most comprehensive dissolution model library available in any web-based platform.
Basic
18 models
Zero Order · First Order · Higuchi · Hixson-Crowell · Korsmeyer-Peppas · Hopfenberg · Baker-Lonsdale · Makoid-Banakar · Peppas-Sahlin (1&2) · Weibull · Gompertz · Logistic · Quadratic · Probit · 2nd/3rd Order · Michaelis-Menten
Sigmoid
11 models
Hill Equation · Richards · Modified Gompertz · Log-Normal · 4-Parameter Logistic · Dose-Response · Logistic 1&2 (DDSolver) · Gompertz 1&2 (DDSolver) · Probit 1 (DDSolver)
Empirical
11 models
Exponential Assoc. · Hyperbolic · Brody Growth · Bertalanffy · Pade · hPLC · Compreg · KP Modified · Makoid-Banakar Mod. · Linear-Exp. · Weibull-Sigmoid
Multi-Phase
7 models
Double Exponential · Triple Exponential · Power-Exponential · Biexponential Absorption · Gallagher-Corrigan · Combined Higuchi+FO · Henriksen
Lag-Time
7 models
KP + Lag · First Order + Lag · Zero Order + Lag · Higuchi + Lag · Weibull (No Lag) · Hixson-Crowell + Lag · Probit Log
Burst Release
5 models
Zero Order + F0 · First Order + Fmax · First Order + Tlag + Fmax · Higuchi + F0 · KP + F0
Fractal
3 models
Fractal First Order · Stretched Exponential · Fractal Weibull
62
Total Models
More than DDSolver (40),
KinetDS (~15) & RKinetDS (36)
combined
Analysis Modules
Everything works together.
Each module shares the same data session — switch between pages without losing your work.
Data Input
Kinetic Fitting
Statistical Analysis
f1 / f2 Similarity
Bootstrap f2
Pro
Compliance Engine
Excel Report
All References
Scientifically Validated
Peer-Reviewed Accuracy
We don't just claim it.
We prove it.
DissolvA's calculation engine was tested against published reference values from DDSolver and RKinetDS — the gold standard tools in pharmaceutical dissolution science.
100%
Validation score · 8 / 8 tests passed
8 independent tests. 8 confirmed results.
Real dissolution data from published studies and analytically generated synthetic datasets were used across three independent test categories.
✓
Literature validation
✓
Synthetic data tests
✓
f2 similarity factor
✓
FDA-compliant formulas
Castro et al. — Albendazole Tablet (Product A)
Mendyk et al. (2026) Dissolution Technologies · Table 3
First-Order
Parameter
Published
DissolvA
Rate K₁
—
K₁
0.143
K₁
0.145
Fit quality
—
R²
0.9991
R²
0.9991
Match confirmed — K₁ and R² align with literature
Castro et al. — Albendazole Tablet (Product A)
Mendyk et al. (2026) Dissolution Technologies · Table 3
Weibull
Parameter
Published
DissolvA
Shape β
—
β
0.6238
β
0.8138
Fit quality
—
R²
0.9998
R²
0.9999
Match confirmed — R² near-perfect at 0.9999
β offset expected — different Weibull variant. RKinetDS reported identical offset (β = 0.8146).
Zhang et al. — DDSolver Profile Comparison Example
Zhang et al. (2010) AAPS J. · BioMed Res Int (2014)
f2 Similarity
Parameter
DDSolver
DissolvA
Similarity
—
f2
23.21
f2
23.2119
Verdict
—
Result
Not similar
Result
Not similar
Perfect match — f2 = 23.2119 vs expected 23.21
Murtaza et al. — Cefixime Microspheres (Formulation 5)
Mendyk et al. (2026) Dissolution Technologies · Korsmeyer-Peppas
Korsmeyer-Peppas
Parameter
Published
DissolvA
Release exp. n
—
n
0.487
n
0.443
Fit quality
—
R²
0.9891
R²
0.9983
Match confirmed — n < 0.45: Fickian diffusion verified
Literature Used in Validation
1
Mendyk, A. et al. — RKinetDS: A Modern R-Based Tool for Dissolution Modeling
Dissolution Technologies, Feb 2026 · doi:10.14227/DT330126P20
Validation source
2
Zhang, Y. et al. — DDSolver: An Add-in Program for Modeling and Comparison of Drug Dissolution Profiles
AAPS Journal, 2010; 12(3): 263–271 · doi:10.1208/s12248-010-9185-1
Validation source
3
Zuo, J. et al. — Evaluation of the DDSolver Software Applications
BioMed Research International, 2014 · doi:10.1155/2014/204925
f2 reference data
4
Ramteke, K.H. et al. — Mathematical Models of Drug Dissolution: A Review
Scholars Academic Journal of Pharmacy, 2014; 3(5): 388–396
Model theory
5
Gao, Y. et al. — Dissolution Kinetics of a BCS Class II API: Diffusion-Based Model Validation
ACS Omega, 2021; 6: 8056–8067 · doi:10.1021/acsomega.0c05558
Diffusion model
Comparison
How DissolvA™ compares.
See how DissolvA™ stacks up against established dissolution software tools used in pharmaceutical research.
Feature DDSolver 1 KinetDS 2 RKinetDS 3
Kinetic Models40~153662
Web-based (no install)——✓✓
f1 / f2 Similarity✓——✓
Bootstrap f2✓——✓
USP Compliance Engine———✓
Excel Report Export✓——✓
Free to use✓✓✓✓
Error bars & SD bands———✓

— Not available in the cited published version. Feature availability based on publicly documented versions as of April 2026. Comparisons are made in good faith based on peer-reviewed publications and publicly available software.
1 Zhang Y et al. AAPS J. 2010;12(3):263–271  ·  2 Mendyk A et al. Dissolution Technol. 2012;19(1):6–11  ·  3 Obajtek N et al. Dissolution Technol. Feb 2026;20–25

User Reviews
Trusted by pharmaceutical researchers
MSK

M. Sinan KAYNAK, PhD

DissolvA Platform Lead

★★★★★

"DissolvA brings together everything pharmaceutical scientists need — kinetic modeling, regulatory compliance, and professional reporting — in a single, elegant web platform."

AY

Ayşe Yılmaz, PhD

Hacettepe University, Pharmaceutical Technology

★★★★★

"Bootstrap f2 analizi için artık ayrı bir yazılıma ihtiyaç duymuyorum. DissolvA ile tüm süreç tek platformda tamamlanıyor, hem hızlı hem güvenilir."

RK

Rahul Krishnamurthy

Senior Formulation Scientist, Mumbai

★★★★★

"The 62-model kinetic library is unmatched. I switched from DDSolver after the first session. The Excel report output alone saves me hours each week."

MB

Marta Borkowska

Regulatory Affairs, Warsaw Pharma CRO

★★★★★

"FDA and EMA compliance checks in one click. The USP monograph engine flagged an OOS result our team had missed. This tool has real regulatory depth."

TW

Thomas Weber

QA Lead, Swiss Generics Manufacturer

★★★★★

"The nonparametric bootstrap f2 with Shah 1998 methodology gives us the statistical confidence our QA submissions require. This is serious pharmaceutical software."

Pricing
Start free. Scale as you grow.
All plans free during beta. Founding members lock in early access pricing — forever.
Core
$0
Forever free
For students and researchers exploring dissolution analysis.
  • f1 / f2 Similarity Analysis
  • 10 Kinetic Models
  • Basic compliance check
  • USP / FDA / EP monograph checks
Get Started Free →
Beta — Free Now
Research
$9
/ month · Free during beta
For academics who need the full kinetic library and reporting.
  • Everything in Core
  • 62 Kinetic Models (full library)
  • Statistical Analysis — MDT, DE
  • Excel Report (6 sheets)
  • Full Compliance Engine — OOS flagging
  • Bootstrap f2 — parametric BETA
Join Research Beta →
Free during beta · Price locks at launch
Most Popular
Pro
$19
/ month · Free during beta
Founding members lock in early access pricing — forever.
  • Everything in Research
  • AI-Powered Model Recommendation BETA
  • Bootstrap f2 — nonparametric BETA
  • Regulatory Guidance Engine BETA
  • CV & Bootstrap Eligibility Auto-Check BETA
  • Full 8-sheet Excel Report
  • Comparative PDF Report
  • Multi-Profile Batch Analysis
  • Custom Branding on Reports
  • Priority Support + Early Module Access
  • IVIVC Module COMING SOON
Join Pro Beta →
Free during beta · Founding price locked at launch
Free to use · No install required

Ready to modernize your
dissolution workflow?

Join researchers worldwide using DissolvA™ for FDA-compliant dissolution analysis.

Launch DissolvA™ Free → Watch Tutorial